藤野武彦のこれまで

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  2. 藤野武彦のこれまで(研究・業績)

過去の研究・業績 (ご覧になりたい年代を選択してください。)

藤野武彦 最近の業績

2017年

  • Efficacy and Blood Plasmalogen Changes by Oral Administration of Plasmalogen in Patients with Mild Alzheimer's Disease and Mild Cognitive Impairment: A Multicenter, Randomized, Double-blind, Placebo-controlled Trial Takehiko Fujino, Tatsuo Yamada, Takashi Asada, Yoshio Tsuboi, ChikakoWakana, Shiro Mawatari, Suminori Kono
    EBioMedicine 17: 199-205, 2017

2016年

  • Measurement of ether phospholipids in human plasma with HPLC-ELSD and LC/ESI-MS after hydrolysis of plasma with phospholipase A1
    Shiro Mawatari, Seira Hazeyama, Takehiko Fujino
    Lipids, 51(8), 997-1006, 2016

2015年

  • Keita Odashiro, Kazuyuki Saito, Takeshi Arita, Toru Maruyama, Takehiko Fujino, Koichi Akashi.
    Impaired deformability of circulating erythrocytes obtained from nondiabetic hypertensive patients: investigation by a nickel mesh filtration technique.
    Clinical Hypertension 21:17, 2015

2014年

  • Keita Odashiro, Toru Maruyama, Koichi Akashi, Aya Sato, Shiro Mawatari, Takehiko Fujino. Marked Impairment of Human Erythrocyte Filterability Caused by Oxidant Stress with AAPH Precedes Oxidative Hemolysis.
    Membrane, 39(1), p. 48-55, 2014
  • Keita Odashiro, Mitsuhiro Fukata, Kazuyuki Saito, Chikako Wakana, Toru Maruyama, Yasuhiro Sasuga, Masaru Fukui, Takehiko Fujino. The effects of lactic acid bacteria-fermented soymilk extract on patients with colonic polyps: a randomized, double-blind, placebo-controlled pilot trial.
    Journal for the integrated study of dietary habits, 25(1), P20-25, 2014

2013年

  • Keita Odashiro, Toru Maruyama, Taku Yokoyama, Hisataka Nakamura, Mitsuhiro Fukata, Shioto Yasuda, Kazuyuki Saito, Takehiko Fujino, Koichi Akashi:Impaired Erythrocyte Deformability in Patients with Coronary Risk Factors:Significance of Nonvalvular Atrial Fibrillation Journal of Atrial Fibrillation 6(3), 7-13, 2013
    Journal of Atrial Fibrillation 6(3), 7-13, 2013

2012年

  • Masataka Ifuku, Toshihiko Katafuchi, Shiro Mawatari, Mami Noda, Kiyotaka Miake, Masaaki Sugiyama and Takehiko Fujino: Anti-inflammatory/anti-amyloidogenic effects of plasmalogens in lipopolysaccharide-induced neuroinflammation in adult mice. Journal of Neuroinflammation 2012, 9:197
    Journal of Neuroinflammation 2012, 9:197
  • Shiro Mawatari, Toshihiko Katafuchi, Kiyotaka Miake and Takehiko Fujino:Dietary plasmalogen increases erythrocyte membrane plasmalogen in rats Lipids in Health and Disease 2012, 11:161
    Lipids in Health and Disease 2012, 11:161
  • Shinji Oma , Shiro Mawatari , Kazuyuki Saito , Chikako Wakana , Yoshio Tsuboi , Tatsuo Yamadaa , Takehiko Fujino.:Changes in Phospholipid Composition of Erythrocyte Membrane in Alzheimer's Disease
    Dement Geriatr Cogn Disord Extra 2012(2),298-303
    Dement Geriatr Cogn Disord Extra 2012(2),298-303
  • T. Katafuchi, M. Ifuku, S. Mawatari, M. Noda,K.Miake,M.Sugiyama,T.Fujino :
    Effects of plasmalogens on systemic lipopolysaccharide-induced glial activation and
    β-amyloid accumulation in adult mice Ann. N.Y. Acad. Sci.( 1261),85-92,2012.
    Ann. N.Y. Acad. Sci.( 1261),85-92,2012
  • K. Saito , K. Odashiro , T. Maruyama , K. Akashi , S. Mawatari , T. Fujino :
    Improvement of diabetic or obese patients’ erythrocyte deformability by the program of the brain-oriented obesity control system (BOOCS) J Physiol Sci Published online : 29 July 2012.
    J Physiol Sci Published online : 29 July 2012.

2011年

  • K. Saito , Y. Kogawa , M. Fukata , K. Odashiro , T. Maruyama , K. Akashi , T. Fujino :
    Impaired deformability of erythrocytes in diabetic rat and human: investigation by the nickel-mesh-filtration technique J Biorheol (25),18-26,2011.
    J Biorheol (25),18-26,2011.

2010年

  • Kyoko Ariyoshi, Toru Maruyama, Keita Odashiro, Koichi Akashi, Takehiko Fujino, Nobuyuki Uesaka : Impaired Erythrocyte Filterability of Spontaneously Hypertensive Rats: Investigation by Nickel Mesh Filtration Technique. Circulation Journal, 74(1), 129-136, 2010.
    Circulation Journal 74(1). 129-136, 2010

2009年

  • Shiro Mawatari, Keita Yunoki, Masaaki Sugiyama, Takehiko Fujino : Simultaneous Preparation of Purified Plasmalogens and Sphingomyelin in Human Erythrocytes with Phospholipase A1 from Aspergillus orizae. Biosci. Biotechnol. Biochem.,73(12),2621-2625,2009.
    Biosci. Biotechnol. Biochem.,73(12), 2621-2625, 2009.

2008年

  • Yunoki K., Kukino O., Nadachi Y., Fujino T., Ohnisi M. : Separation and determination of functional complex lipids from chicken skin. J. Am. Oil Chem. Soc., 85,427-433, 2008.
    J. Am. Oil Chem. Soc., 85,427-433, 2008

2007年

  • 藤野 武彦:Catecholamine Rheopathy −揺らぎの新たな表現?−
    日本バイオレオロジー学会,21(2),41-42,2007
    日本バイオレオロジー学会,21(2),41-42,2007
  • Shiro Mawatari, Yumika Okuma, Takehiko Fujino: Separation of intact plasmalogens and all other phospholipids by a single run of high-performance liquid chromatography: Analytical Biochemistry 370(1), 54-59, 2007
    Analytical Biochemistry 370(1), 54-59, 2007
  • 丸山徹、関律子、岡村孝、井出達也、神代龍吉、佐田通夫、藤野武彦、上坂伸宏:肝硬変症における赤血球変形能の定量的検討.第29回日本膜学会年会.May.10-11,2007.東京
  • 丸山徹、関律子、岡村孝、井出達也、神代龍吉、佐田通夫、藤野武彦、上坂伸宏:C型慢性肝炎における赤血球変形能と治療の影響.第30回日本バイオレオロジー学会年会.Jun.14-15,2007.北海道

2006年

  • Fumiaki Kuma, Norihiro Ueda, Hiroyuki Ito, Toru Maruyama, Yoshikazu Kaji, Takehiko Fujino, Mine Harada : Effects of Ultrasound Energy Application on Cardiac Performance in Open-Chest Guinea Pigs.-An In Vivo Pilot Study-. Circulation Journal. 70(10), 1356-1361,2006.
    Circulation Journal 70(10), 1356-1361, 2006.
  • Kyoko Ariyoshi, Yasushi Sasaki, Aya Satoh, Takehiko Fujino, Nobuhiro Uesaka, Toru Maruyama : Impaired Filterability of Erythrocytes from Subjects with Cold Intolerance. Journal of Japanese Society of Biorheology, 20(2), 40-48, 2006
    Journal of Japanese Society of Biorheology, 20(2), 40-48, 2006.

2005年

  • Yasushi Ohnishi, Takehiko Fujino, Aya Satoh, Seiko Takeda, Mine Harada, Nobuhiro Uesaka, Toru Maruyama : Effects of Oligomeric Procyanidins (OPCs) on Human Erythrocyte Filterability and Microcirculation. Journal of Japanese Society of Biorheology, 19(2), 24-33, 2005.
    Journal of Japanese Society of Biorheology, 19(2), 24-33, 2005

2004年

  • Okamoto K, Maruyama T, Kaji Y, Harada M, Mawatari S, Fujino T, Uyesaka N:Verapamil Prevents Impairment in Filterability of Human Erythrocytes Exposed to Oxidative Stress.Japanese Journal of Physiology.54:39-46,2004.
    Japanese Journal of Physiology.54:39-46,2004.
  • Iwata H, Ukeda H, Maruyama T, Fujino T, Sawamura M: Effect of carbonyl compounds on red blood cells deformability. Biochem Biophys Res Commun 321: 700-706, 2
    Biochem Biophys Res Commun 321: 700-706, 2004
  • 丸山徹、船越亜弥、武田誠子、川床須美子、長谷由美子、高垣欣也、上坂伸宏、藤野武彦:   松樹皮抽出物がヒト赤血球の変形能と循環に及ぼす作用.第52回 レオロジー討論会   Sept 22-24, 2004, 弘前
  • Mawatari S, Saito K, Murakami K, Fujino T:Absence of Correlation Between Glycated Hemoglobin and Lipid Composition of Erythrocyte Membrane in Type 2 Diabetic Patients. Metabolism - Clinical and Experimental 53 (1), 123-127, 2004.
    Metabolism - Clinical and Experimental 53 (1), 123-127, 2004.

2003年

  • Mawatari S, Ohnishi Y, Kaji Y, Maruyama T, Murakami K, Tsutsui K, Fujino T:High Cholesterol Diets Induce Changes in Lipid Composition of Rat Erythrocyte Membrane Including Decrease in Cholesterol, Increase in α-Tocopherol and Changes in Fatty Acids of Phospholipids. Biosci Biotechnol Biochem.67(7):1457-1464,2003.
    Biosci Biotechnol Biochem.67(7):1457-1464,2003.
  • 大柿哲朗、丸山徹、藤野武彦、白川太郎、小倉理一:高塩分濃度海水温浴時の生理的応答.健康科学25:21-29,2003.
    健康科学25:21-29,2003.
  • 丸山徹、大柿哲朗、藤野武彦、白川太郎、小倉理一:高塩分濃度海水温浴時の心機能および一般血液動態. 健康科学 25: 31-35, 2003
    健康科学 25: 31-35, 2003
  • 丸山徹、岡本和彦、馬渡志郎、藤野武彦、上坂伸宏:Ca拮抗剤verapamilは赤血球のtertial butyl hydroperoxideによる酸化障害を軽減する.膜シンポジウム講演要旨集 121-124, 2003
  • 丸山徹、岡本和彦、馬渡志郎、藤野武彦、上坂伸宏:tertial butyl hydroperoxideによる酸化ストレスが赤血球に及ぼす作用:verapamilは酸化ストレスによる赤血球変形能の低下を阻害する.第51回 レオロジー討論会講演要旨集 53-54, 2003

2002年

  • 藤野武彦:BOOCSダイエットクッキング.小学館.2002.
  • 丸山徹、斉藤和之、伊東裕幸、加治良一、藤野武彦、上坂伸宏:糖尿病における赤血球変形能の解析.第50回レオロジー討論会講演要旨集 51-52, 2002
  • 丸山徹、斉藤和之、伊東裕幸、加治良一、藤野武彦、上坂伸宏:ニッケルメッシュ濾過法を用いた糖尿病における赤血球変形能の解析.膜シンポジウム講演要旨集 33-36, 2002

2001年

  • Ogaki T,Saito A,Hotta N,Ueda N,Kanaya S,Fujino T:Plasma sulpho-conjugated Catecholamine Responses to moderate steady-state exercise:Adv.Exerc.Sports Physiol7(3):87-92,2001
    Adv.Exerc.Sports Physiol7(3):87-92,2001
  • 清水扶美,小宮秀一,大柿哲朗,藤野武彦:卵胞期と黄体期における有酸素性運動中の代謝・ホルモン動態の特徴:健康科学23:65-73,2001
    健康科学23:65-73,2001

2000年(紀要)

  • 堀田昇,大柿哲朗,金谷庄蔵,藤野武彦,馬渡志郎,中島敏郎,筒井浩一郎,中島幸一:成人女性肥満者に対する栄養補助食品を用いた食事療法-最大下運動時呼吸循環応答に対する改善効果-:久留米大学健康・スポーツ科学センター研究紀要8:1-5,2000.
    久留米大学健康・スポーツ科学センター研究紀要8:1-5,2000.
  • 藤野武彦,千々岩智香子,中村真理子,下川さえ子,安藤孫衛,安藤 寛,本田 悳,近藤 乾,平田喜代美,熊井昭彦,西 福江,大村 武,橋本武夫:母親の食事と母乳・血液成分への影響 - 食事と母子の血清脂質,血清蛋白,乳児体重との関係 -:Neonatal Care 2000秋期増刊:121-126,2000
    Neonatal Care 2000秋期増刊:121-126,2000
  • 中村真理子,下川さえ子,平田喜代美,安藤孫衛,安藤 寛,西 福江,藤野武彦,千々岩智香子,熊井昭彦,橋本武夫:母親の食事と母乳・血液成分への影響-食事ガイドラインが異なる3施設の食事内容分析-:Neonatal Care 2000秋期増刊:113-120,2000]
    Neonatal Care 2000秋期増刊:113-120,2000

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(株)レオロジー機能食品研究所 最近の業績

論文

  • 2016
    Measurement of ether phospholipids in human plasma with HPLC-ELSD and LC/ESI-MS after hydrolysis of plasma with phospholipase A1
    Shiro Mawatari, Seira Hazeyama, Takehiko Fujino
    Lipids, 51(8), 997-1006, 2016
  • 2012
    Shinji Oma , Shiro Mawatari , Kazuyuki Saito , Chikako Wakana , Yoshio Tsuboi , Tatsuo Yamadaa , Takehiko Fujino.:Changes in Phospholipid Composition of Erythrocyte Membrane in Alzheimer's Disease
    Dement Geriatr Cogn Disord Extra 2012(2),298-303
    Dement Geriatr Cogn Disord Extra 2012(2),298-303

    T. Katafuchi, M. Ifuku, S. Mawatari, M. Noda,K.Miake,M.Sugiyama,T.Fujino :
    Effects of plasmalogens on systemic lipopolysaccharide-induced glial activation and
    β-amyloid accumulation in adult mice Ann. N.Y. Acad. Sci.( 1261),85-92,2012.
    Ann. N.Y. Acad. Sci.( 1261),85-92,2012

    K. Saito , K. Odashiro , T. Maruyama , K. Akashi , S. Mawatari , T. Fujino :
    Improvement of diabetic or obese patients’ erythrocyte deformability by the program of the brain-oriented obesity control system (BOOCS) J Physiol Sci Published online : 29 July 2012.
    J Physiol Sci Published online : 29 July 2012.
  • 2011
    K. Saito , Y. Kogawa , M. Fukata , K. Odashiro , T. Maruyama , K. Akashi , T. Fujino :
    Impaired deformability of erythrocytes in diabetic rat and human: investigation by the nickel-mesh-filtration technique J Biorheol (25),18-26,2011.
    J Biorheol (25),18-26,2011.
  • 2010
    Kyoko Ariyoshi, Toru Maruyama, Keita Odashiro, Koichi Akashi, Takehiko Fujino, Nobuyuki Uesaka : Inpaired Erythrocyte Filterability of Spontaneously Hypertensive Rats:Investigation by Nickel Mesh Filtration Technique. Circulation Journal, 74(1),129-136,2010.
  • 2009
    Shiro Mawatari, Keita Yunoki, Masaaki Sugiyama, Takehiko Fujino : Simultaneous Preparation of Purified Plasmalogens and Sphingomyelin in Human Erythrocytes with Phospholipase A1 from Aspergillus orizae. Biosci. Biotechnol. Biochem.,73(12),2621-2625,2009.
  • 2008
    Yunoki K., Kukino O., Nadachi Y., Fujino T., Ohnisi M. : Separation and determination of functional complex lipids from chicken skin. J. Am. Oil Chem. Soc., 85,427-433, 2008.
  • 2007
    Shiro Mawatari, Yumika Okuma, Takehiko Fujino : Separation of Intact Plasmalogens and all other Phospholipids by a Single Run of High-Performance liquid Chromatography. Analytical Biochemistry, 370, 54-59,2007.

    藤野 武彦:Catecholamine Rheopathy −揺らぎの新たな表現?−
    日本バイオレオロジー学会,21(2),41-42,2007
  • 2006
    Fumiaki Kuma, Norihiro Ueda, Hiroyuki Ito, Toru Maruyama, Yoshikazu Kaji, Takehiko Fujino, Mine Harada : Effect of Ultrasound Energy Application on Cardiac Performance in Open-Chest Guinea Pigs.-An In Vivo Pilot Study-. Circulation journal. 70(10), 1356-1361,2006.

    Kyoko Ariyoshi, Yasushi Sasaki, Aya Satoh, Takehiko Fujino, Nobuhiro Uesaka, Toru Maruyama : Impaired Filterability of Erythrocytes from Subjects with Cold Intolerance. Journal of Japanese Society of Biorheology, 20(2),40-48,2006.
  • 2005
    Yasushi Ohnishi, Takehiko Fujino, Aya Satoh, Seiko Takeda, Mine Harada, Nobuhiro Uesaka, Toru Maruyama : Effects of Oligomeric Procyanidins (OPCs) on Human Erythrocyte Filterability and Microcirculation. Journal of Japanese Society of Biorheology, 19(2), 24-33, 2005.
  • 2004
    Shiro Mawatari, Kazuyuki Saito, Kaori Murakami, Takehiko Fujino : Absence of Correlation Between Glycated Hemoglobin and Lipid Composiotion of Erythrocyte Membrane in Type 2 Diabetic Patients. Metabolism, 53(1),123-127,2004.

    Kazuhiko Okamoto, Toru Maruyama, Yoshikazu Kaji, Mine Harada, Shiro Mawatari, Takehiko Fujino, Nobuhiro Uesaka : Verapamil Prevents Impairment in Filterability of Human Erythrocytes Exposed to Oxidative Stress. Japanese Journal of Physiology, 54(1), 39-46,2004.

    Hiroyoshi Iwata, Hiroyuki Ueda, Toru Maruyama, Takehiko Fujino, Masayoshi Sawamura : Effect of Carbonyl Compounds on Red Blood Cells Deformability. Biochemical and Biophysical Research Communications. 321, 700-706,2004.
  • 2003
    Shiro Mawatari, Yasushi Ohnishi, Yoshikazu Kaji, Toru Maruyama, Kaori Murakami, Koichiro Tsutsui, Takehiko Fujino : High-cholesterol Diets Induce Changes in Lipid Composiotion of Rat Erythrocyte Membrane Including Decrease in Cholesterol, Increase in α-Tocopherol and Changes in Fatty Acids of Phospholipids. Biosci. Biotechnol.Biochem., 67(7),1457-1464,2003.

総説

  • 藤野武彦:
    メタボ・うつ病・認知症を克服する新理論.Medical Confidential DEC. P6〜9.2014
  • 藤野武彦:
    「認知症」要因の真髄に迫る!脳の健康 vol 01.2014
  • 丸山徹, 岡本和彦:
    ニッケルメッシュ濾過法による赤血球変形能の定量的解析.
    福岡医学会雑誌 95: 131-138, 2004
  • 府中英孝、柚木恵太、松山弘幸、藤野武彦、大西正男、小玉芳郎、杉山雅昭
    :親鳥由来の機能性リン脂質:スフィンゴミエリンの抗高脂血症及び抗高血糖効果.
    ブレインテクノニュース(141)P13〜19.2010
  • 藤野武彦:血液の健康と食品とのかかわり.FOOD STYLE 21(165) P23〜25.2011

学会発表

  • 若菜智香子、斉藤和之、所紀子、古本真理、奥山孝子、府中英孝、杉山雅昭、藤野武彦:スフィンゴミエリン高濃度含有チキンミートボールによる糖代謝の改善−二重盲検試験にひょる評価.日本統合医療学会九州支部大会ヨーガ部会設立記念発表会.Dec.4,2010.福岡市
  • 丸山徹、船越亜弥、武田誠子、川床須美子、長谷由美子、 高垣欣也、上坂伸宏、藤野武彦: 松樹皮抽出物(フラバンジェノール)の赤血球変形能改善作用. 第26回 日本膜学会年会 May 20-21, 2004, 東京
  • Uyesaka N, Koyama T, Maruyama T, Seki R, O'Rear EA, Shio H: Establishment of a new quantitative filtration apparatus to evaluate erhythcyte deformability. 第81回 日本生理学会大会 June 2-4, 2004, 札幌
  •  
  • 丸山徹、船越亜弥、武田誠子、川床須美子、長谷由美子、 高垣欣也、上坂伸宏、藤野武彦: フラバンジェノールはヒト赤血球の変形能を改善する: Nisckel mesh filtration法に よる検討. 第27回 日本バイオレオロジー学会年会 June 10-11, 2004, 東京
  • 関律子、岡村孝、井出達也、佐田通夫、丸山徹、 藤野武彦、上坂伸宏: C型慢性肝疾患患者における赤血球変形能の定量的 解析と治療効果の関連. 同上
  • 丸山徹、船越亜弥、武田誠子、川床須美子、長谷由美子、 高垣欣也、上坂伸宏、藤野武彦: 松樹皮抽出物がヒト赤血球の変形能と循環に及ぼす作用. 第52回 レオロジー討論会 Sept 22-24, 2004, 弘前

シンポジウム

  • 丸山徹、佐藤亜弥、武田誠子、川床須美子、長谷由美子、 高垣欣也、上坂伸宏、藤野武彦: 松樹皮抽出物の循環改善作用: Nickel mesh filtration 法と レーザードップラー血流計測法による検討. 膜シンポジウム 2004「膜最前線」 Nov 18-19, 2004, 京都

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